Messenger RNA (mRNA) nanoparticle tumour vaccination

JACOB/MESELSON/BRENNER: DISCOVERY OF MESSENGER RNA (mRNA)

While for 25 years it had been clear the DNA contained the basic genetic information, by 1960 it was still not at all clear how that information was expressed. How did a difference in the sequence of nucleotide bases translate into the differences between an elephant and a flea? The boundaries of the problem had been roughed out even before the era of Watson-Crick DNA. It was shown that all of ...

Messenger RNA.

Who discovered messenger RNA?

The announcement of the discovery of messenger RNA (mRNA) and the cracking of the genetic code took place within weeks of each other in a climax of scientific excitement during the summer of 1961. Although mRNA is of decisive importance to our understanding of gene function, no Nobel Prize was awarded for its discovery. The large number of people involved, the complex nature of the results, and...

Haemoglobin messenger RNA.

This is a short review on the isolation and translation in heterologous Systems of a 9 s RNA which carries the information of haemoglobin. Rabbit haemodobin (Hb) messenger RNA (mRNA) was the first eukaryotic genetic message to be isolated, quite a long time ago (1). This was mainly due to the fact that mammalian reticulocytes offer the favourable opportunity of being highly specialized cells wh...

Nuclear RNA - Protein Interactions Messenger RNA Processing

Eucaryotic messenger RNA precursors are processed in nuclear ribonucleoprotein particles (hnRNP). Here recent work on the structure of hnRNP is reviewed, with emphasis on function. Detailed analysis of a specific case, the altered assembly of hnRNP in heatshocked Drosophila and mammalian cells, leads to a general hypothesis linking hnRNP structure and messenger RNA processing. A unifying princi...